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This family comprises only one protein, SET7/9, which mono-methylates histone at H3K4 ninety two KMT7 was discovered to methylate, in addition to histone, quite a lot of non-histone proteins, including p53, DNA methyltransferase 1 (DNMT1), [Lawyer Articles](https://git.akel.cl/eulaliabey6308/hortense2017/wiki/Vyom+Becomes+A+Member+Of+The+Indus+Entrepreneurs+%2528TiE%2529+Bangalore+Chapter) estrogen receptor alpha (ERα), nuclear factor kappaB (NFκB), and components of the TATA binding protein (TBP) complex, TBP-related factors TAF10 and TAF7 ninety three The consensus recognition sequence in substrates for SET7-mediated lysine methylation, K/R-S/T-Ok (target lysine is daring), can also be recognized by the H3K4 demethylase KDM1A/LSD1, which is capable of removing the methyl mark on most of those substrates 17 , ninety four Subsequently KMT7/KDM1A has emerged as a basic model for dynamic lysine methylation of each histone and non-histone proteins.
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The members of the SUV39 household discussed above are involved in both euchromatin and heterochromatin, however another member of the identical household, G9a, is the predominant histone H3 K9 methyltransferase in mammalian euchromatin 14 There are two isoforms of G9a in the mouse: the brief type (GenBank accession number NP_671493 ) corresponds to human G9a and the long type ( NP_665829 ), which lacks intron one, has additional Arg-Gly repeats at the amino terminus.
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