diff --git a/Glycogen-Storage-Disease-%28GSD%29.md b/Glycogen-Storage-Disease-%28GSD%29.md new file mode 100644 index 0000000..2e2f417 --- /dev/null +++ b/Glycogen-Storage-Disease-%28GSD%29.md @@ -0,0 +1 @@ +
Such a scheme serves as a template for the lactate shuttling current in the mammalian CNS. An virtually contemporaneous report prolonged this scheme to apply to the mammalian brain, but with notable differences and [additions](https://sportsrants.com/?s=additions). It was to prove one of the crucial contentious papers in the sphere of mind energy metabolism and the debate raging around the subject persists. The paper described experiments carried out using cultures of mouse cerebral neurones and astrocytes, and demonstrated just a few key features, which had been stoichiometrically strong (Pellerin and Magistretti, 1994). The background to the research was the realization that if metabolic signaling were to occur between neurones and astrocytes within the mammalian CNS, there should exist a signaling mechanism whereby the neurones sign to astrocytes their need for supply of metabolic substrate. The signaling mechanism must have the next traits: (1) it must be related to the frequency of activity of the neurones i.e., the release of the compound should be associated to the activity of the neurones, (2) it should be sensed by the astrocyte i.e., there have to be mechanism(s) whereby the astrocyte senses the molecule, and (3) there must exist a system or course of whereby the concentration of the molecule is decreased upon cessation of activity i.e., there should be an effective buffering system that reduces the concentration of the molecule after exercise.

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The Dawn Phenomenon refers to rising blood sugar levels typically between 2 a.m. 8 a.m. that are the results of cortisol, glucagon, growth hormone, and adrenaline (a.ok.a. Glycogen is basically saved glucose launched by your liver. Because you’ve been "fasting" all night time whereas asleep, your liver releases glucagon which is then transformed back into glucose and serves as a gas source your body’s energy wants until you eat breakfast. If you’ve ever tried intermittent fasting and struggled with spiking blood sugars while skipping breakfast, glucagon is likely a giant a part of that spike. Adrenaline also will increase blood sugar levels by signaling to your liver to release glucose. Growth hormone increases blood sugar levels by making your body’s muscle and fat tissues less sensitive to insulin, thus requiring extra to get the job finished. The Somogyi Effect refers to severe low blood sugar that may occur whereas you’re sleeping, adopted by your liver releasing glycogen with a view to carry you as much as a protected degree.
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